Here you will find a list of tips or hints that will help you play this great game.
Tip 1: Try Different Weapons and Different Approaches
The default weapon for your class is not always the best weapon to use. Each weapon has its own advantages and disadvantages. Try out other options to get a feel for what you like and get used to using different weapons.
The same goes for combat tactics. Experiment with your class and combat tactic to get a feel for the weapon and what you like to do.
Tip 2: Use Your Squad, and Hack Everything
Your squadmates and the tech skills they bring to the battlefield can be invaluable. Use your squadmates to take out enemy specialists, provide sniper fire, provide healing, etc.
On missions, try to hack everything. Hacking can reveal hidden items, open up new areas, disable turrets, etc. Hacking is also a great way to score some extra loot.
Tip 3: Use the Galaxy Map to Travel Quickly
The galaxy map is a great way to get from point to point. If you want to get from one planet to another, don't waste time flying from one planet to another. Use the galaxy map to jump to a nearby planet and then take a shuttle or a transit to get to your destination.
Tip 4: Don't Rely on Cover
You are not invulnerable while in cover. Enemies will often move in closer to you while you are in cover and either hit you with a grenade or weapon fire to destroy the cover you are using. If you are in cover try to move to a new location when the opportunity presents itself.
Tip 5: Take Time to Explore the Galaxy
The galaxy is huge, and you cannot visit all the planets in one playthrough. Take some time to explore some of the planets you come across. You never know what you might find.
There's tons of minor things you can do to make your gameplay experience better. The most important thing is to remember to use the training simulator to get a sense of how your powers and weapons work. You can also be smart about your reputation and use the Paragon/Renegade system to your advantage. Finally, learn how to use your powers effectively.